ULISES has developed a number of useful resources available to the public, from official documents to deliverables, scientific papers, and a set of factsheets.
Take a look at them!

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Validation in vitro and in vivo of nanoparticle treatment to induce anti-tumoral alloreactivity

FACTSHEETS - PDF — 275.19 KB — 27 Jun 2024

As part of ULISES, project partner IMIB-Arrixaca has carried out in vitro validation. This involved performing cytotoxicity assays using human pancreatic adenocarcinoma cells (PANC-1). These were transformed with the nanoparticles to express allogeneic Human Leucocyte Antigen (HLA) molecules. For in vivo validation, a tumour-xenotransplant mouse model treated with nanoparticles was used to evaluate anti-tumour alloreactivity. The in vitro results indicate that the transformed cells become vulnerable to the effector mechanisms of the immune system and can be efficiently targeted. The in vivo results are promising, but they will require better therapeutic approaches.


Characterisation of a set of biological materials from PDCA patients

FACTSHEETS - PDF — 330.46 KB — 27 Jun 2024

As a biobank, Instituto Valenciano de Oncologia has collected, processed, stored, characterised and analysed biological materials patients affected by pancreatic ductal adenocarcinoma (PDAC): fresh frozen materials, formalin and fixed paraffin-embedded (FFPE) tissues, plasma and peripheral blood mononucleated cells.



A comprehensive transcriptional signature in pancreatic ductal adenocarcinoma reveals new insights into the immune and desmoplastic microenvironments

PAPERS - PDF — 4.48 MB — 18 Oct 2023

In this paper, the ULISES partner Instituto Valenciano de Oncologìa (IVO) presents a comprehensive meta-analysis identifying 1153 significantly dysregulated genes, which mainly impact extracellular matrix remodeling and the immune system.

IVO identifies two signatures of twenty-eight immune-related genes and eleven stroma-related genes influencing PDAC patients’ survival. Additionally, five immune genes are associated with PDAC prognosis for the first time.


Report on establishment of optimal collection, processing, storing and analysis of biological materials from patients

DELIVERABLES - PDF — 9.71 MB — 04 Sep 2023

The purpose of this deliverable is to describe the collection, processing, storing and analysis processes of human biological samples derived from PDAC patients.